Diffusely abnormal white matter converts to T2 lesion volume in the absence of MRI-detectable acute inflammation. Digital Cross Connect System or “DCS” is a function which provides automated Cross Connection of Digital Signal Level 0 or higher transmission bit rate digital channels within physical interface facilities. Types of DCS include but are not limited to DCS 1/0s, DCS 3/1s, and DCS 3/3s, where the nomenclature 1/0 denotes interfaces typically at the DS1 rate or greater with Cross Connection typically at the DS0 rate.
These observations stress the importance of developing imaging techniques able to capture early inflammatory cortical demyelination in order to better understand the disease pathogenesis and to determine the impact of potential disease-modifying therapies on the cortex. Automated separation of diffusely abnormal white matter from focal white matter lesions on MRI in mu… Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary progressive multiple sclerosis. Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary…
The pathologic hallmark of MS consists of focal demyelinated plaques within the CNS, with variable degrees of inflammation, gliosis, and neurodegeneration. Active MS lesions show a profound pathologic heterogeneity with four major patterns of immunopathology, suggesting that the targets of injury and mechanisms of demyelination in MS may be different in different disease subgroups. MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features; surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four immunopatterns need to be developed in order to recognize them in the general nonbiopsied MS population. Inflammatory cortical demyelination is an important early event in the pathogenesis of MS and may be driven by meningeal inflammation.
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Background Previous histopathology and MRI studies have addressed the differences between focal white matter lesions and diffusely abnormal white matter in multiple sclerosis . These two categories of white matter T2-weighted hyperintensity show different degrees of demyelination, axonal loss and immune which of the following is not true concerning the zebra mussel in the united states? cell density on histopathology, potentially offering distinct … This article summarizes the pathologic features of multiple sclerosis and other inflammatory demyelinating diseases and discusses neuropathologic studies that have yielded novel insights into potential mechanisms of demyelination.